Instant Broad Spectrum Disease Screening Coming of Age

Genomics-Transcriptomics-Proteomics-Metabolomics Broad Spectrum Disease Screening

Genomics-Transcriptomics-Proteomics-Metabolomics
This image illustrates the interactive domains of gene expression, from genome to metabolite. Using screening microarrays at each step displays gene expression at multiple levels, providing a multidimensional view of normal and pathologic processes.

From Singapore: Micro-RNA Screening Will Allow Instant Disease Diagnosis

Spotting the spread of diseases such as cancer in their early stages can make a huge difference to the likelihood of being able to beat them into submission, and scientists in Singapore have developed a new biosensor that could provide on-the-spot diagnoses to do just that.

The new sensor picks up on biomarkers known as microRNAs (a class of RNAs or ribonucleic acids) that help translate genetic DNA information into protein. MicroRNAs can act as signposts to various diseases, and because they’re well-preserved in fluids such as urine and blood, they’re an ideal way of quickly testing for signs of trouble in the body. __ Read More

The Singapore scientists are helping to fill in more pieces of the diagnostic puzzle. The more parts of this dynamic puzzle which can be captured at one instant, the more knowledge we will have of the state of our bodies in their interactive entirety.

DNA Screening by Microarray

DNA Screening by Microarray

DNA Microarray screening has been around for decades now, but is becoming more affordable and more widely available. Such tests look for genes that are associated with known diseases and pathologies, so that the person can adjust their lifestyle if necessary to avoid unnecessary hardship.

MicroRNA and Messenger RNA

MicroRNA and Messenger RNA

The addition of RNA screening to the arsenal provides a broader spectrum view of the gene expression pathways. Both micro-RNA and messenger RNA perform vital roles in gene expression in health and disease.

Protein screening by microarray exposes the next step in gene expression. Proliferation of abnormal proteins is a tipoff to underlying disease processes — often in the very early stages of pathology.

A Broader View of Proteomics

A Broader View of Proteomics

Protein microarray screening and diagnostic testing has a broad range of applications in the research lab, pharmaceutical development, and in clinical medicine. It is another dynamic puzzle piece that will be used in systems medicine and systems biology to understand normal and abnormal cell processes — and to help intervene wisely when necessary.

The final “omics” of the topmost image — metabolomics — falls under the domain of chemical testing in medicine that has been dominant for over a century now. By adding microarrays and complex microfluidic processes to the study of the metabolome, researchers and clinicians can look at a massive range of metabolic parameters at the final stage of molecular gene expression.

63 Years Ago, Few People Imagined the Potential of Watson and Crick’s Discovery

April 25, 1953, Nature published a paper “Molecular Structure of Nucleic Acids (PDF)” by two relatively unknown scientists. Since then, progress into the many mechanisms of gene expression has been fast, broad, and deep. Thanks to advanced methods in computing, robotics, and symbiotic fields of science, we are approaching the time when individuals can perform comprehensive screening and diagnostic testing of themselves, at home.

As more people acquire 3-D printing equipment that is capable of creating chemicals, drugs, and useful therapeutic devices, they will be able to react appropriately to the data that their home diagnostic modules are supplying to them.

Independence from large institutions such as health care, pharma, medical insurance, etc. is just one component of the progression toward independence from government.

Very few voters of the Anglosphere and Europe think along those lines. That is why they will always be slaves to governments and the lying populist shills who stir their emotions in order to keep the monstrous system going.

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2 Responses to Instant Broad Spectrum Disease Screening Coming of Age

  1. AbelardLindsey says:

    Independence from large institutions such as health care, pharma, medical insurance, etc. is just one component of the progression toward independence from government.

    100% spot-on. This is the form my libertarian world-view takes. The development and use of technology to enable one’s autonomy from large-scale institutions, which I regard as hopelessly corrupt.

    Very few voters of the Anglosphere and Europe think along those lines. That is why they will always be slaves to governments and the lying populist shills who stir their emotions in order to keep the monstrous system going.

    This is precisely the reason why such autonomy is absolutely essential.

  2. roger says:

    Until the genome was mapped they didn’t understand it. I’m not sure they do now.
    The reigning belief, before the genome was mapped, was 1 gene = 1 protein. That blew up when the “race to the genome” was completed. How do we know that this claim is any more truthful?

    PS: been paying attention to the genetic vs epigenetic cancer arguments going on?

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