Is Growing Old Better than the Alternative?

Old age is accompanied by a host of losses and indignities. Your appearance will suffer, no matter what you do. You may retain your mental faculties, but what about your health? Why worry about your virility when you cannot eat and eliminate wastes without a good deal of hullabaloo? And sleep . . . what’s that? The long voyage into senescence is not a trip for weaklings or sissies. A common cold might kill you. So what can you do to mitigate the down side of the experience?

Salient Declines in Hormone Production

As a person grows older, blood levels of several hormones decline appreciably. Human growth hormone, DHEA, melatonin, testosterone, estrogen, thymosins, and other important hormones are produced at lower levels with increased age. Even worse, the ability of the body to utilize the hormones in circulation is impaired due to loss of hormone receptor function. For example, insulin levels may stay the same or increase, but insulin sensitivity often declines.

Hormone replacement may help in many cases, by increasing quality of life. It is not clear that such hormone replacement will result in a longer life. But in all honesty, it is quality of life that most of us are interested in. So hormone replacement therapy is gaining in popularity across the western world, although in terms of sophistication the approach is not quite ready for prime time.

Anti-Aging From the Bones

Bone hormones appear to provide benefits even outside the skeleton. The benefits of bone hormones osteocalcin and DPP4:

“If you exercise regularly, then it stimulates your bone to make more osteocalcin, and that will have these beneficial effects on muscle and brain,” he says. “From epidemiological studies, we know that people who are very active tend to have less of a cognitive decline with age than sedentary people. With time, maybe people will be more aware of this connection, and think of their bone health as being just as important as other aspects of staying healthy.”

Ongoing research in this area also suggests that exercising more during the teenage years and early adulthood can continue to have a protective effect on bone and other aspects of health much later in life.

… Osteocalcin is not the only bone hormone to have caught the attention of scientists, however. At the Mayo Clinic, Sundeep Khosla has been studying a hormone called DPP4, which is made by cells on the outer layers of bone, called osteoclasts, and appears to play a role in how bone regulates blood sugar.

Khosla is particularly interested in this hormone because the drug denosumab – which is clinically prescribed to osteoporosis patients to try and slow down the rate of bone loss – seems to have a positive effect on DPP4 as well. In a study of osteoporosis patients taking denosumab published earlier this year, he noticed that those also suffering from diabetes experienced an improvement in their symptoms. __ Source

COVID-19 Kills More Old People

Older people have more problems with their immune systems, both with the quality of antibodies produced by B cells, and with the quality of T cell response to infections.

“T cells are a type of white blood cells that are specialised in recognising virus-infected cells, and are an essential part of the immune system,” says Marcus Buggert, assistant professor at the Center for Infectious Medicine, Karolinska Institutet, and one of the paper’s main authors. “Advanced analyses have now enabled us to map in detail the T-cell response during and after a COVID-19 infection. Our results indicate that roughly twice as many people have developed T-cell immunity compared with those who we can detect antibodies in.” — Marcus Buggert, assistant professor at the Center for Infectious Medicine, Karolinska Institutet

The virus from Wuhan takes full advantage of any and all immune deficiencies, and attacks the weakest with utmost ferocity.

T-Cells Suffer When the Thymus Declines with Age

Thymic Involution

Chronic thymus involution associated with aging results in less efficient T-cell development and decreased emigration of naïve T cells to the periphery. Thymic decline in the aged is linked to increased morbidity and mortality in a wide range of clinical settings. Negative consequences of these effects on global health make it of paramount importance to understand the mechanisms driving thymic involution and homeostatic processes across the lifespan. __

But all is not lost. The above paper looks at some attempts at reconstituting the thymus, even in advancing years.

COVID-19 Losing Its Epidemic Status in US?

Officials, politicians, and journalists are panicked out of their shorts, but according to the US CDC the epidemic is on shaky legs.

The United States now has so few deaths due to COVID-19 that the Centers for Disease Control and Prevention reported Friday it is approaching the threshold for dipping below the level of an epidemic.

The CDC defines an epidemic as an outbreak from which the number of deaths per week exceeds a given percentage of total deaths within the nation. The number of deaths from COVID-19 has steadily declined since hitting its peak in early May after it began spiking in the second week in March. __ Source


Meanwhile, Schools are Producing a Generation of Sissies and Barbarians Unfit for Growing Old

You can call it a cultural revolution, in reference to the mid-20th-century movement in China by that name. And there seem to be many similiarities, in terms of sheer mindless fanatical violence. Under a radical leftist mayor, New York City is transforming itself into a third world zone where hunger, disease, and shortages of all kinds are becoming more possible.

This is lawless New York – a city that was once America’s glittering crown jewel but which risks descending into mob rule.

The sissies of fake hate crimes are another example of the low quality of today’s young. Is this a reflection of ongoing dysgenic decline, or does cultural decline play the largest role here?

Clearly cultural decline is much faster, and can achieve the destruction of a formerly vibrant society in very rapid order. But do not write off the effect of dysgenic decline, which can produce significant effects on culture within just a few generations.

If, as it appears, we are heading toward an Idiocracy, why should we bother trying to improve economic conditions and extend the lifespans of the coming generations of mental and moral cretins? Because they are not all like that, and some of them may be your own children and grandchildren.

Even if they have been sent down the wrong trail by certain teachers, journalists, politicians, and rabble-rousers, we cannot give up hope for them. It is simply not in us to do that.

But for us to keep trying, we have to keep living — probably for longer than we may have expected until now. We need to be strong to compensate for the weakness, ignorance, degeneracy, and insanity that has engulfed the minds of many of the young.

You cannot build a strong society on a rotten human substrate. The knowledgeable and highly skilled are leaving the workforce, and younger generations are not stepping up to the plate.

The rapid decline in critical infrastructures that occurred in South Africa after the ANC took power, is likely to occur in a slower and more spotty manner in Europe and the Anglosphere, as older generations retire and younger generations show themselves not up to the task of taking over critical roles.

The problem is not just a decline in average IQ, taking place around the world. It is not just a problem of lower birthrates in advanced nations and among the more educated and intelligent people of the world. Fewer skilled and intelligent workers must keep the lights on for growing numbers of unskilled and low intelligence people. That is how democracies turn into idiocracies.

There is not much room for fence-sitting on this issue. If you want a box seat high above the action, you had best be able to afford it. Otherwise you may find yourself in the middle of the action, when all you wanted to do was sit this one out.

Whatever life holds in store for you, you will be better able to face it by being strong, healthy, savvy, and as prepared as possible. It is never too late to have a Dangerous Childhood © .


Transplanting young eosinophils into old animals had rejuvenating effect

Humanin, a recently discovered anti-aging peptide produced in mitochondria

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