Not Your Grandfather’s Melatonin

Melatonin indirectly regulates ACE2 expression and has been deemed to be a promising agent in the fight against coronavirus in several studies, as it could prevent infection of these cells. At the same time, it also prevents the premature cell death of these infected cells (apoptosis), which not only slows the spread of infection but also buys the immune system more time to adapt to the infection. __ Melatonin and Viral Infections

Melatonin, COVID, Cytokine Storm

In the old days, we believed that the hormone melatonin was only produced in the pineal gland — specifically to help regulate the day/night sleep cycle. But now we are discovering a larger world where melatonin plays a more important role.

Melatonin was initially discovered in and thought to be exclusively a product of the vertebrate pineal gland. However, in consideration of the identification of melatonin in prokaryotic bacteria… and the uncommonly high levels of assayable melatonin in mitochondria (9), it was speculated and eventually documented that this indoleamine is synthesized in this organelle (10). Given that most cells (a few exceptions) contain mitochondria, it is now believed that melatonin production occurs in most cells in all organisms. __ Melatonin Helps Neutralize COVID Cytokine Storm

Melatonin is usually used as a “milder sleeping pill.” But it seems likely that the antioxidant/anti-inflammatory hormone is useful for a far wider range of ailments than insomnia and jet lag.

… endogenous melatonin production diminishes markedly with age especially in frail older individuals. This is consistent with the more serious nature of a COVID-19 infection in the elderly. __ Melatonin and COVID

Melatonin is just one of the many important hormones that declines in concentration and effectiveness with aging. Older individuals enjoy less of the benefits of melatonin — and of several other hormones including human growth hormone, DHEA, testosterone, estrogen, thymosins, thyroid, and many more.

In the case of the cytokine storm which can accompany severe infection with the Chinese coronavirus from Wuhan, the lack of melatonin in the cells of the elderly can lead to an inflammatory holocaust that affects cells all over the body.

Other Possible Uses of Melatonin

Other benefits of melatonin include general neuroprotective effects, as melatonin is a powerful antioxidant. Melatonin also has several anti-cancer properties, and is currently being investigated for its role in fighting breast cancer. It does not appear to have much of an effect on lean mass or body fat, but it potentially stops your body from gaining more fat. Melatonin supplementation also benefits eye health, possibly reduces tinnitus, and improve mood (by helping you get better sleep).

… Smokers tend to be less responsive to supplementation, and older people tend to not produce as much during night time. Depression has also been associated with lower melatonin levels. __ Examine

Melatonin can also be used to ameliorate side effects of stopping smoking, to reduce some of the unpleasant side effects of cancer chemotherapy, and for many other purposes.

It’s A Powerful Antioxidant
Melatonin increases the production of antioxidant enzymes in the body that protect against oxidative stress and support mitochondria function. Its potent action inhibits cellular atrophy and also protects against toxins that can disrupt mitochondrial function, leading to a plethora of neurodegenerative diseases (these are diseases caused by the progressive damage of nerve cells.)

It Boosts Immunity
Melatonin supports immune function. It gives your body the strength to fight against infections, diseases and symptoms of premature aging. It also has the ability to act as a stimulant in immunosuppressive diseases because of its potent anti-inflammatory properties.

It Reverses Circadian Rhythm Sleep Disorders
Melatonin has the ability to shift biological rhythms. This makes it useful in the treatment of various circadian rhythm sleep disorders, such as advanced and delayed sleep phase disorders, jet lag and shift-work disorder.

It Benefits Heart Health
Melatonin offers cardio-protective benefits. Its potent anti-inflammatory and antioxidant abilities can help prevent heart attacks and strokes. Its free radical scavenger activity makes it a great natural alternative to treat and prevent cardiovascular diseases.

It Lowers Blood Pressure
Melatonin also has anti-hypertensive effect, which keeps blood pressure under control. Since melatonin acts favorably on different levels of hypertension, including organ protection and with minimal side effects, it can be used as a supporting therapy in patients with hypertension.

It Improves Gut Health
Melatonin is also produced by the stomach because it is crucial for smooth digestion. For those dealing with digestive issues, melatonin can be a natural treatment for gut dysbiosis, ulcers, stress-induced stomach damage and inflammation of the stomach. It can be effective in treating colitis, IBS, irritable bowel syndrome, and even various cancers.

It’s Useful In The Treatment OF GERD
Melatonin is a surprising remedy for acid reflux. It helps in this digestive disorder by strengthening the lower esophageal sphincter (LES). Relaxation of LES is a major reason for acid reflux. Also, studies have found lower levels of melatonin in patients of acid reflux.

It Can Be Used For Migraine Prevention And Treatment
If migraines are wreaking havoc on your life, melatonin supplements can help reduce the frequency and intensity of these painful, debilitating attacks. 3 mg of melatonin is effective for migraine prevention. It can also be useful in the treatment of cluster headaches.

It’s Important For Eye Health
Melatonin supports a healthy vision by preventing the death of cone cells that help in identifying color. It also improves the functioning of nerve cells crucial for vision and protects the cells that make eye pigment. It can also decrease elevated pressure in the eye from glaucoma and prevent the death of nerve cells in the eye.

It Can Improve Insulin Function
Low night-time secretion of melatonin nearly doubles the risk of developing diabetes. In fact, melatonin improves insulin balance and protects insulin-producing cells in the pancreas from cell death. It can be used as a supporting therapy for treating prediabetes, diabetes type 2, Polycystic ovary syndrome (PCOS), and insulin resistance.

Beneficial For Alzheimer’s And Parkinson’s Disease
The antioxidant abilities of melatonin can help alleviate symptoms of Alzheimer′s and Parkinson′s disease. With age, decreased melatonin activity can increase the risk of Alzheimer’s and Parkinson’s. Melatonin therapy improves sleep and overall rest, which can bring relief from symptoms.

Improve Thyroid Function
Aging can make the thyroid functioning rather sluggish, which is where melatonin’s protective abilities step in. For menopausal women, melatonin therapy can improve thyroid function and treat mood disorders.

Treat PMS
Research has shown that low melatonin levels play a role in PMDD, a severe form of PMS. Melatonin therapy can keep you symptom-free through the luteal phase or the second part of your menstrual cycle. It can also be useful to treat perimenopause and menopause symptoms in older women. Scientific evidence sheds light on melatonin’s ability to treat infertility in both men and women as well.

Can Help In Managing Chronic Pain
Besides its potent antioxidant and anti-inflammatory action, melatonin also has analgesic properties. This makes it useful for managing chronic painful conditions like fibromyalgia, headaches, irritable bowel syndrome, chronic back pain, and rheumatoid arthritis. Patients suffering from fibromyalgia – a condition that results in chronic widespread pain in muscles and connective tissues with no apparent cause, can benefit from melatonin supplements.
__ Source

It seems that the health benefits of melatonin are closely linked to some of the benefits of healthy mitochondria. The more ways we can keep our mitochondria healthy, the more health benefits we will enjoy.

Keep in mind that the benefits of melatonin supplementation for many of the above maladies has only been suggested by medical research — not proven. It would seem that the ongoing Wuhan coronavirus epidemic would make an ideal testing ground for some of the claims being made for melatonin.

The side effects of using low to moderate doses of melatonin are minimal for most people. Use your best judgment, while consulting your most trusted health authorities.

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