Different human breeding populations evolved on different continents, reacting to disparate environmental conditions in different genetic ways. The outward differences between different breeding populations are obvious. The inward differences — including a stratification by IQ due to differently evolved brains — are not quite as obvious.
Can These IQ Differences Be Erased by New Neuroscience?
This Discovery May Help
“Researchers around the world have tried many ways to generate neurons in the lab, using stem cells and other means, so we can study them better, as well as to use them to replace lost neurons in neurodegenerative diseases,” said Fu, who is a Distinguished Professor in the Department of Cellular and Molecular Medicine at UC San Diego School of Medicine. “The fact that we could produce so many neurons in such a relatively easy way came as a big surprise.” __ Source
Here is the background:
In 2013 an interdisciplinary team from both UCSD in La Jolla and Wuhan, China, published research showing that fibroblasts could be converted to neurons when they were depleted of “a single RNA binding polypyrimidine-tract-binding (PTB) protein.” More recent research published by some members of the same team show that astrocytes in the mouse midbrain can be converted to normal dopamine producing neurons — thus reversing many symptoms of a mouse model of Parkinson’s Disease — a revolutionary feat if it is replicated in further research and in larger mammals, specifically humans.
Using a chemically induced model of Parkinson’s disease in mouse, we show conversion of midbrain astrocytes to dopaminergic neurons, which provide axons to reconstruct the nigrostriatal circuit. Notably, re-innervation of striatum is accompanied by restoration of dopamine levels and rescue of motor deficits. A similar reversal of disease phenotype is also accomplished by converting astrocytes to neurons using antisense oligonucleotides to transiently suppress PTB. These findings identify a potentially powerful and clinically feasible approach to treating neurodegeneration by replacing lost neurons. __ Nature
More on the history of this potentially revolutionary research from the Fight Aging! website:
Several years ago, a postdoctoral researcher was using a technique called siRNA to silence the PTB gene in connective tissue cells known as fibroblasts. It’s a tedious process that needs to be performed over and over. He got tired of it and instead used a different technique to create a stable cell line that’s permanently lacking PTB. At first, the postdoc complained about that too, because it made the cells grow so slowly. But then he noticed something odd after a couple of weeks – there were very few fibroblasts left. Almost the whole dish was instead filled with neurons. In this serendipitous way, the team discovered that inhibiting or deleting PTB transforms several types of mouse cells directly into neurons.
Recently, researchers applied this finding in what could one day be a new therapeutic approach for Parkinson’s disease and other neurodegenerative diseases. Just a single treatment to inhibit PTB in mice converted native astrocytes, star-shaped support cells of the brain, into neurons that produce the neurotransmitter dopamine. As a result, Parkinson’s disease symptoms disappeared. The treatment works like this: The researchers developed a noninfectious virus that carries an antisense oligonucleotide sequence – an artificial piece of DNA designed to specifically bind the RNA coding for PTB, thus degrading it, preventing it from being translated into a functional protein and stimulating neuron development.
The researchers administered the PTB antisense oligonucleotide treatment directly to the mouse’s midbrain, which is responsible for regulating motor control and reward behaviors, and the part of the brain that typically loses dopamine-producing neurons in Parkinson’s disease. A control group of mice received mock treatment with an empty virus or an irrelevant antisense sequence. In the treated mice, a small subset of astrocytes converted to neurons, increasing the number of neurons by approximately 30 percent. Dopamine levels were restored to a level comparable to that in normal mice. What’s more, the neurons grew and sent their processes into other parts of brain. There was no change in the control mice. By two different measures of limb movement and response, the treated mice returned to normal within three months after a single treatment, and remained completely free from symptoms of Parkinson’s disease for the rest of their lives. In contrast, the control mice showed no improvement. __ from FightAging!
According to researchers, astrocytes in other parts of the brain can be converted to the appropriate type of neuron for that brain region. The next step involves moving to higher mammals, as well as testing the technique in a larger number of animal disease models — to demonstrate the newly created neurons’ ability to connect with the appropriate neuronal networks for both local and global brain connectivity.
This is Not Just a Treatment for Parkinson’s Disease!
If astrocytes can be converted to site-appropriate neurons which then connect normally into local and global brain neuronal networks, this kind of treatment may cautiously be applied to any neurodegenerative disease in the brain — including many forms of mental retardation. The approach seems too good to be true, which is why it was so hard for these researchers to get their results published.
They originally submitted their study to another publication, back in 2017, but were rejected. “The three peer reviewers who had looked over the paper called us themselves to congratulate us,” said Fu. According to Fu, the reviewers raved, “This is so exciting” and “this is a major breakthrough.” Fu and the team were happy the research was well received. However, the publication’s editor was very hesitant. A fourth reviewer wondered if the team had interpreted their experiments correctly. The paper wasn’t accepted.
So, the disappointed team submitted their paper to Nature, where it was eventually published. But only after a few years and a lot more work. Yet again another set of reviewers immediately called the team to congratulate them on their “revolutionary work.” And a fourth reviewer suggested a set of experiments the researchers could do to cast away any further doubt. “They suggested 28 more experiments,” Fu said. “We did every single one. That’s why the paper is so long!” __ Nautil.us
But sooner or later, this or a similar approach to the neuronal rejuvenation of the human brain was very likely to be discovered — as long as Marxists are not allowed to totally destroy western science and the productive society that has underwritten western science and innovation for centuries now.
Can Low IQ Genotypes be Converted to Normal IQ Phenotypes?
This is the question that haunts our leftist overlords of government, media, academia, and other cultural institutions. Leftism denies the apparent evolutionary outcome of unequal IQs for different breeding populations which evolved under different sets of environmental constraints. This denial of a central and obvious phenomenon contains the downfall of any leftist society which enshrines this forced egalitarian ideology into inflexible policy. It doomed the USSR, it doomed the Warsaw Pact governments, it doomed North Korea, Cuba, and Venezuela, and it doomed Communist China — until the CCP was forced to relax its fatal grip on mainland Chinese society just enough to allow capitalist reforms and pragmatic workarounds to save the middle kingdom’s people from starvation and ruin.
If low IQ genotypes can be salvaged to live productive normal IQ phenotypic lives, then there will be no more need for all the top-down engineered riots, phony lockdowns, climate apocalypses, racial grievances, reparation demands, affirmative action, and generation after generation of families and cultures mired in crime and government dependency.
How might it be done?
Different regions of the brain specialize in different somatic (body sensing and autonomic/endocrine control) and cognitive functions. By artificially supplementing the neuronal networks that deal with higher level cognitive functions such as memory, analyses, and prediction, a person who was otherwise destined for a lower-than-normal IQ might be given a cognitive boost into the normal IQ range. Of course something would have to be done about “poor impulse control,” “slow autonomic response,” and “poor executive functions” overall. But given the high heritability of all of those things — including IQ — it seems likely that artificial brain cell boosting might be a possible corrective for all of those crucial parameters.
Another approach to this evolutionary problem of cognitive inequality may be developed should a more Mendelian approach to the genetics of IQ be discovered. The “polygene” approach to “genes and IQ” has very limited utility, in terms of boosting the IQs of humans who find themselves near to bottom of the heap.
The discovery of a very small subset of human gene alleles that play key roles in a person’s IQ would potentially rock the boat of modern science and culture at large.
But the ability to grow a large number of new neurons which are capable of fitting functionally into different regional centers of the brain, may help to “normalize” distinct IQ distributions and may provide a less politically volatile approach to de-radicalizing government, higher education, and eventually our inbred media.
A perfect egalitarianism is as unattainable as a perfect utopia. But if the masses of humans live free of meaningful deprivation — and if the propaganda and physical assaults on ordinary humans from aggressive and power-hungry ideologues in government/media/academia/etc. meant to create imagined deprivations, were to be reduced — then the mere impression of “a good life” could be far more easily attained by most anyone in free societies. Particularly by those who are cognitively capable of fitting into a productive and satisfying role.