Category Archives: Longevity

Who Wants to Live Forever? Saga of NAD+

Posted on 16 January, 2023 by alfin2101

Recent years have witnessed a resurgence of interest in nicotinamide adenine dinucleotide (NAD+) biology. This has been driven in part by the discoveries that two intermediates of NAD+ biosynthesis, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), effectively increase NAD+ concentration … Continue reading →

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Rejecting Your Most Cherished Beliefs

Posted on 22 July, 2022 by alfin2101

Have you ever changed your mind about something that was of critical importance to you? Have you had beliefs that you were sure you would never change, but which you were forced to change by the evidence? That has happened … Continue reading →

Posted in Energy, Knowledge, Longevity, Philosophy, Russia, Ukraine | 1 Comment

Quest for Immortality: Progress in Senolytics

Posted on 17 March, 2022 by alfin2101

Senescent cells are often called “zombie cells,” because they don’t want to die. They just hang around in your body and cause cancer, dementia, diabetes, wrinkled skin, arthritis, and a host of other painful and disfiguring signs of aging. Eliminating … Continue reading →

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Lose Up to 40% of Body Weight as Fat!

Posted on 21 September, 2021 by alfin2101

Treating obese mice with the cytokine known as TSLP led to significant abdominal fat and weight loss compared to controls, according to new research published Thursday in Science from researchers in the Perelman School of Medicine at the University of Pennsylvania. Unexpectedly, … Continue reading →

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More on Breathing

Posted on 30 December, 2020 by alfin2101

According to the famous Framingham Study, the strongest predictor of longevity is lung capacity. People with small and inefficient lungs tend to get sick and die quicker. Greater lung capacity promises greater living capacity… from Chapter 4 of “Breath” by … Continue reading →

Posted in Biomedicine, Longevity | 3 Comments

Is Growing Old Better than the Alternative?

Posted on 6 July, 2020 by alfin2101

Old age is accompanied by a host of losses and indignities. Your appearance will suffer, no matter what you do. You may retain your mental faculties, but what about your health? Why worry about your virility when you cannot eat … Continue reading →

Posted in Dysgenics, Idiocracy, Longevity, Politics | Tagged | Comments Off on Is Growing Old Better than the Alternative?

The Slow Death from Smoldering Inflammation

Posted on 30 December, 2019 by alfin2101

Acute, short-term inflammation is important to fight infections and to heal from injuries. But smoldering, chronic inflammation will eventually kill you. Slow, chronic inflammation is linked to several diseases of ageing including diabetes, cardiovascular disease, joint diseases, COPD, and inflammatory … Continue reading →

Posted in Longevity | Tagged | 2 Comments

Three Years You May Want to Hibernate

Posted on 7 December, 2019 by alfin2101

Years 34, 60, and 78: When Bad Things Happen Scientists working at Stanford University, Albert Einstein College of Medicine, and institutions in Germany and Italy, have determined that protein markers for human ageing change significantly during three years of a … Continue reading →

Posted in Genetics and Gene Expression, Longevity, Sex Differences | Tagged , | Comments Off on Three Years You May Want to Hibernate

Can Rapamycin Help You Live to 200?

Posted on 22 November, 2019 by alfin2101

The mTOR pathway is switched on when lots of nutrients are present and it stimulates growth and reproduction. If you impair the pathway, or make it less efficient, an organism will prepare for a situation with less nutrients, and begin … Continue reading →

Posted in Longevity | Tagged | 2 Comments

Raising the Retirement Age to 130

Posted on 19 November, 2018 by alfin2101

The official retirement age in many countries is between the ages 60 and 65. Workers are generally expected to live another 15 years or so, on average for a lifespan of roughly 80 years. But what if the expected lifespan … Continue reading →

Posted in Longevity | Tagged | 4 Comments

The Tragic Misconstruction of the Human Life Cycle

Posted on 6 January, 2018 by alfin2101

Modern humans have somehow come to believe that the human life cycle stops in young adulthood. Choosing to forego the critical step of procreation — and spending almost all their resources trying to maintain themselves at the young adult stage … Continue reading →

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Falling Through the Earth’s Centre: How Long to Reach the Other Side?

Posted on 24 August, 2016 by alfin2101

The gravitational effects on a body falling through the centre of the Earth to the other side, is an interesting problem. The video above introduces an idea or two which may be new to you, even if you have thought … Continue reading →

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Happiness Deconstructed

Posted on 12 July, 2016 by alfin2101

What is Happiness? First, a few things that happiness IS NOT: bitter hostility, helpless loneliness, a despairing dearth of choices, a lack of personal confidence based upon genuine personal incompetence, the absence of any meaningful purpose. The Happiness of Pleasure … Continue reading →

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Anti-Ageing Interventions

Posted on 9 June, 2016 by alfin2101

A Few Biomarkers or “Mileposts” of Ageing It will be very difficult to measure the success of anti-ageing interventions without using a number of validated biomarkers that reflect the current state of ageing of the organism or person. Here are … Continue reading →

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Sweet AGE-ing: Focus on Advanced Glycation End-Products

Posted on 23 May, 2016 by alfin2101

Advanced glycation end products, (AGEs) are proteins or lipids that become glycated as a result of exposure to sugars.[1] They can be a factor in aging and in the development or worsening of many degenerative diseases, such as diabetes, atherosclerosis, … Continue reading →

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Newer Life Extension Pathways

Posted on 23 December, 2015 by alfin2101

Mitochondrial Health Microarray screening revealed that epigenetic downregulation of the nuclear-coded GCAT gene, which is involved in glycine production in mitochondria, is partly responsible for these aging phenotypes. Treatment of elderly fibroblasts with glycine effectively prevented the expression of these … Continue reading →

Posted in Disruptive Technologies, Longevity, Practical Medicine | 1 Comment

Genes Out of Thin Air, and Other Wonders

Posted on 2 September, 2015 by alfin2101

Human DNA comprises 98% non-coding DNA and only 2% coding DNA. But that is not the end of the story. Noncoding DNA is defined as all of the DNA sequences within a genome that are not found within protein-coding exons, … Continue reading →

Posted in Genetics and Gene Expression, Longevity, Science | Tagged | 6 Comments

At What Age Should a Woman Become Pregnant?

Posted on 16 June, 2015 by alfin2101

What are the Best Ages for Women to Become Pregnant Historically, across cultures, it has been the norm for older males to marry younger females, so that women bore children early in life. In recent years, with the widespread postponing … Continue reading →

Posted in Fertility, Genetics and Gene Expression, Longevity, Medicine, Sex | Tagged , | 2 Comments

Young Men Pay for College While Boosting Female Sexuality and Healthy Pregnancies

Posted on 31 May, 2015 by alfin2101

London, UK — The secret to a long life may lie in the human sperm now. In a new study conducted by Graz University scientists in Austria, it has been found that a compound called spermidine, which is found is … Continue reading →

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Fountain of Youth: Pouring Young Blood Into Old Bodies?

Posted on 4 April, 2015 by alfin2101

The search for the fountain of youth is following many different paths, including the “seven-fold path” of SENS, suspended animation via cryonic vitrification, tweaking the immune system to boost human resilience, increasing the length of telomeres, regenerative medicine, stem cells, … Continue reading →

Posted in Longevity, Optimism, Regenerative Medicine | Tagged | 2 Comments